- UFVJM
- Rodovia MGT 367, 5000, km 583, Campus JK, Alto da Jacuba, Diamantina / MG - CEP: 39.100-000
- ppgcs@ufvjm.edu.br
- 38 3532-1200 - Ramal: 8810
- 38 3532-6099
Disciplina
CSA611 | TÉCNICAS EXPERIMENTAIS EM MODELO ANIMAL
Créditos: 2 | Créditos computáveis
Obrigatoriedade: Disciplina não obrigatória
Periodicidade [período(s) de oferta]: 1, 2
Desde 01/06/2021
Na disciplina Técnicas Experimentais em Modelo Animal é abordado um conteúdo, teórico-prático, envolvendo o ensino de Técnicas Experimentais para a obtenção de modelos animais de importância na pesquisa científica. Enfoca-se, também, alguns conceitos éticos sobre a utilização de animais em atividades de pesquisa, além de noções gerais de instalações, manutenção e manejo de roedores.
1. DE MOLON RS, PARK CH, JIN Q, SUGAI J, CIRELLI JA. Characterization of ligature-induced experimental periodontitis. Microsc Res Tech. 2018 Dec;81(12):1412-1421.
2. FAZAN Jr R.; SILVA, V.J.D. e SALGADO, H.C. Modelos de hipertensão arterial. Rev Bras Hipertens 8: 19-29, 2001.
3. GURGEL BC, Ribeiro FV, Silva MA, Nociti FH Jr, Sallum AW, Sallum EA, Toledo SD, Casati MZ. Selective COX-2 inhibitor reduces bone healing in bone defects. Braz Oral Res. 2005 Oct-Dec;19(4):312-6.
4. LEE, V.WS; HARRIS, D.CH. Adriamycin nephropathy: A model of focal segmental glomerulosclerosis. Nephrology 16 (2011) p.30–38.
5. ROJO-ORTEGA, J. M.; GENEST, J. A method for production of experimental hypertension in rats. Canadian Journal of Physiology and Pharmacology, 1968, 46 (6), 883-885.
6. VAN EDEN W, Wagenaar-Hilbers JPA, Wauben MHM (2001) – Adjuvant Arthritis in the Rat. Current Protocols Immunology. In: Animal Models for Autoimmune and Inflammatory Disease. John Wiley & Sons, chapt 15, pp:15.4.1-8.
7. VINEGAR R, Truax JF, Selph JL, Johnston PR, Venable AL, McKenzie KK (1987) - Pathway to carrageenan-induced inflammation in the hind limb of the rat. Fed. Proc. 46:118-126
1. DAMATTA, R.A. Modelos animais na pesquisa biomédica - Animal models in biomedical research. Scientia Medica (Porto Alegre) 2010; volume 20, número 3, p. 210-211.
2. DI ROSA M, Giroud JP, Willoughby DA (1971) – Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentin. J. Pathol. 104: 15-29.
3. DIAS, R.; TRINDADE, J.C.S.; RUDGE, M.V.C.; CURI,P.R. Hipertensão Arterial Experimental e Prenhez em Ratas: Uso do Modelo Goldblatt I (1 rim - 1 clipe). RBGO 21 (4): 209-214, 1999.
4. DUARTE PM, Gonçalves PF, Casati MZ, Sallum EA, Nociti FH Jr. Age-related and surgically induced estrogen deficiencies may differently affect bone around titanium implants in rats. J Periodontol. 2005 Sep;76(9):1496-501.
5. MALTOS KLM,, Menezes GB, Rocha OA, Caliari MV, Santos JMM, Ferreira-Alves DL, Duarte IDG, Francischi JN (2004) - Vascular and cellular responses to pro-inflammatory stimuli in rat dental pulp. Arch Oral Biol 49:443-450
6. MUKHERJEE A, Hale VG, Borga O, Stein R (1996) - Predictability of the clinical potency of NSAIDs from the preclinical pharmacodynamics in rats. Inflamm Res 45:531-540
7. NAVAR, L. G.; ZOU, L.; VON THUN, A.; WANG, C.T.; IMIG, J.D.; MITCHELL, K.D. Unraveling the Mystery of Goldblatt Hypertension. News Physiol. Sci. V.13. August 1998.
8. OKUDA S.; OH, Y.; TSURUDA, H; ONOYAMA, K.; FUJIMI, S.; FUJISHIMA, M. Adriamycin-induced nephropathy as a model of chronic progressive glomerular disease. Kidney International, v.29 (1986), p.502—510.
9. PINTO, Y.M.; PAUL, M.; GANTEN, D. Lessons from rat models of hypertension: from Goldblatt to genetic engineering. Cardiovascular Research, v. 39 (1998) 77–88.
10. SOUSA, D. N.; FERREIRA, V.M.; SOUZA, J. A. C.; STEFANI, C. M.; RORIZ, V. M. Efeito Tópico da Sinvastatina no Metabolismo Ósseo: revisão crítica da literatura. Rev Odontol Bras Central 2017; 26(77): p.1-8.
11. TATSUO MAKF, Carvalho WM, Silva CV, Miranda AEG, Ferreira SH, Francischi JN (1994) – Analgesic and antiinflammatory effects of dipyrone in rat adjuvant arthritis model. Inflammation. 18(4):399-405
12. TAVARES-MURTA BM, Cunha FQ, Ferreira SH (1998) – The intravenous administration of tumor necrosis factor alpha, interleukin 8 and macrophage-derived neutrophil chemotatic factor inhibits neutrophil migration by stimulating nitric oxide production. British Journal Pharmacol. 124: 1369-1374.
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